Ebselen Alters Mitochondrial Physiology and Reduces Viability of Rat Hippocampal Astrocytes
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چکیده
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High and low temperatures affect rat hippocampal synaptosome’s viability and functions
Introduction: Synaptosomes are sealed particles that contain mitochondria, cytoskeleton and vesicles which are necessary to synaptic events like neurotransmitter release and uptake in the nervous system. However, the effect of high and low temperatures on synaptosome membrane integrity and function during a time course after its extraction is less known. The purpose of this study was to assess ...
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GABA (γ-aminobutyric acid), the predominant inhibitory neurotransmitter in the mature mammalian brain, is excitatory for neurons during early development upon GABAA receptor activation. In astrocytes, GABA induces intracellular Ca2+ transients by activation of both, GABAA and GABAB receptors. GABAB receptor-mediated [Ca]i increases are involved in neuron-glia interaction by potentiating inhibit...
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ژورنال
عنوان ژورنال: DNA and Cell Biology
سال: 2013
ISSN: 1044-5498,1557-7430
DOI: 10.1089/dna.2012.1939